Statin-induced autoimmune necrotizing myositis
نویسندگان
چکیده
منابع مشابه
Atorvastatin-induced necrotizing autoimmune myositis
The general aim of this study was to evaluate the disease spectrum in patients presenting with a pure polymyositis (pPM) phenotype. Specific objectives were to characterize clinical features, autoantibodies (aAbs), and membrane attack complex (MAC) in muscle biopsies of patients with treatment-responsive, statin-exposed necrotizing autoimmune myositis (NAM). Patients from the Centre hospitalier...
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A 76-year-old man with a history of two prior strokes complicated by residual mild cognitive impairment, atrial fibrillation, coronary artery disease, diabetes mellitus type 2, congestive heart failure, dyslipidemia, and stage 3 chronic kidney disease was admitted for failure to thrive and functional decline. Two months prior, he had been briefly hospitalized for fatigue and inability to walk. ...
متن کاملIdentifying statin-associated autoimmune necrotizing myopathy.
Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this e...
متن کاملLaminin-induced autoimmune myositis in rats.
The present study aimed to examine if immunization with laminin causes myositis in rats and whether the pathologic findings mirror human polymyositis and dermatomyositis. Rats were immunized with an emulsion of laminin and complete Freund's adjuvant. As a result, muscle fiber necrosis with infiltrating macrophages was frequently observed and mononuclear cells were observed in the endomysium. Th...
متن کاملMyositis, Pyomyositis, and Necrotizing Fasciitis
Skin and soft-tissue infections (SSTIs) are common in children and usually are recognized easily and treated, with few residual long-term problems. However, although rare, myositis, pyomyositis, and necrotizing fasciitis soft-tissue infections can be difficult to diagnose in their early stages and despite appropriate antibiotic therapy are associated with substantial morbidity and mortality. Th...
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ژورنال
عنوان ژورنال: Reumatologia/Rheumatology
سال: 2015
ISSN: 0034-6233
DOI: 10.5114/reum.2015.57641